CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 1,902 enrolled
Drug / intervention
Implantable Defibrillator +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00617175
NCT00617175Phase 4Completed
CompareCT.gov

ADVANCE III: Avoid DeliVering TherApies for Non-sustained Arrhythmias in ICD PatiEnts III

Medtronic Cardiac Rhythm and Heart Failure·interventional·Posted Feb 15, 2008·Updated Jul 2, 2025

In Brief

A Phase 4 clinical trial evaluating Implantable Defibrillator for Heart Disease. Completed, enrolled 1,902 participants across 91 sites in 14 countries.

Detailed Summary

To demonstrate a reduction in the number of ventricular therapies (ATP and Shocks) delivered for treating spontaneous arrhythmia episodes with a fast cycle length (CL≤ 320ms) as a consequence of self-termination and better arrhythmia discrimination due to a greater number of R-R intervals necessary to detect ventricular events.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Disease
CountriesBelgium, Denmark, Finland, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Russia, Saudi Arabia, South Africa, Spain
Collaborators--

Timeline

Phase 4CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 15, 2008
Enrollment StartMar 1, 2008
Primary CompletionDec 1, 2011
Study CompletionFeb 1, 2012
TodayJul 2, 2026
Enrollment to primary: 3.8 yearsPosted 18.4 years ago

Interventions

Implantable Defibrillatordevice

Number of 30 out of 40 intervals to detect (NID)Fast Ventricular Tachycardia

Implantable Defibrillatordevice

number of 18 out of 24 intervals to detect (NID)Fast Ventricular Tachycardia