At a glance
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Do Endometrial Implantation Markers Predict in Vitro Fertilization-embryo Transfer Cycle Outcomes in Endometriosis Patients Pretreated With Leuprolide Acetate in Depot Suspension?
In Brief
A Phase 4 clinical trial evaluating Leuprolide acetate in depot suspension and No intervention for Endometriosis and Infertility. Completed, enrolled 37 participants across 1 site.
Detailed Summary
This prospective randomized trial evaluates whether one can predict which infertile women with endometriosis who are candidates for in vitro fertilization will benefit from prolonged therapy with a GnRH agonist by the determination of the absence of endometrial expression of the integrin, alpha v, beta 3 vitronectin. This is a prospective randomized trial in which all patients will undergo endometrial biopsy prior to initiation of ovarian stimulation for in vitro fertilization and then undergo randomization to a three month course of a depot preparation of the GnRH agonist leuprolide acetate in depot suspension prior to ovarian stimulation or standard therapy. prio
Study Details
Timeline
Interventions
Leuprolide acetate in depot suspension 3.75 mg intramuscularly every 28 days x 3