CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 184 enrolled
Drug / intervention
Tutoring Program I +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00624234
NCT00624234N/ACompleted

Neurobiology and Treatment of Reading Disability in Neurofibromatosis Type 1 (NF-1)

Vanderbilt University·interventional·Posted Feb 27, 2008·Updated Jul 8, 2025

In Brief

A clinical study evaluating Tutoring Program I and Tutoring Program II for Neurofibromatosis Type 1 and Reading Disabilities. Completed, enrolled 184 participants across 1 site.

Detailed Summary

The goal of this trial is to determine if children with neurofibromatosis type 1 who have reading disabilities respond the same way-both behaviorally and neurobiologically-to specialized treatment programs as children with idiopathic reading disabilities do, and to determine which intervention is best for particular learner profiles.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 27, 2008
Enrollment StartFeb 1, 2006
Primary CompletionMar 1, 2013
Study CompletionJan 1, 2017
TodayJul 2, 2026
Enrollment to primary: 7.1 yearsPosted 18.3 years ago

Interventions

Tutoring Program Ibehavioral

Tutoring Program I is a structured multi-sensory program that is designed to gradually present the range of sounds and letters with focus on accuracy of phonological concepts and application of those concepts in phrases and sentences. The instruction uses a sequenced defined lesson plan with accuracy and automaticity criteria for skill progression. A range of manipulative and kinesthetic activities is outlined to maintain learner engagement in the intensive intervention design.

Tutoring Program IIbehavioral

Tutoring Program II is designed to teach visual and speech elements of reading separately at first, and then bring them together for maximum efficiency. The program uses the idea of teaching concepts about the structure of words. For example, students transfer the rules they have learned about one vowel or structure to another without specific instructions on the new one. Tutoring Program II incorporates pictures and activities to help remember strategies for increasing basic reading skills. Speed drills are also used for development of decoding automaticity.