CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 36 enrolled
Drug / intervention
Botulism Antitoxin Bivalent (Equine) Types A and B +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00636519
NCT00636519Phase 1Completed

Botulism Antitoxin Effects on Paralysis Induced by Type A and Type B Botulinum Neurotoxins in the Extensor Digitorum Brevis Muscle

Emergent BioSolutions·interventional·Posted Mar 14, 2008·Updated Mar 18, 2024

In Brief

A Phase 1 clinical trial evaluating Botulism Antitoxin Bivalent (Equine) Types A and B and Botulism Antitoxin Heptavalent (Equine) Types A-G for Healthy Volunteers. Completed, enrolled 36 participants across 2 sites.

Detailed Summary

The primary purpose of this study is: 1. To evaluate the model determined by the ability of botulism antitoxin (bivalent, Aventis) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage A. 2. To assess the ability of botulism antitoxin (heptavalent, Cangene) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage B.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 1CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 14, 2008
Enrollment StartFeb 1, 2008
Primary CompletionOct 1, 2009
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 18.3 years ago

Interventions

Botulism Antitoxin Bivalent (Equine) Types A and Bbiological

One vial of Botulism Antitoxin Bivalent(Equine) Types A and B (1:10 in saline) or an Equivalent Volume of Placebo on Day 0 in Stage A

Botulism Antitoxin Heptavalent (Equine) Types A-Gbiological

One vial of Heptavalent Botulism Antitoxin (1:10 in saline) or an Equivalent Volume of Placebo on Day 0 in Stage B