At a glance
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Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery
In Brief
A clinical study evaluating midazolam, clonidine, and 1 other intervention for Anxiety and Pain. Completed, enrolled 60 participants across 1 site.
Detailed Summary
alpha2-agonists like clonidine offer several useful effects that make these drugs an interesting alternative to benzodiazepines for pharmacological premedication. We therefore sought to determine the effect of pre-anesthetic medication with clonidine vs. midazolam in a randomized, double-blind, placebo controlled study. Effects of pre-anesthetic medication were assessed on (1) bispectral index (BIS),(2) sedation score and visual analog scales for anxiety and pain, (3) neuropsychologic tests to assess cognitive function and (4) circulating stress hormones.
Study Details
Timeline
Interventions
midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time
pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
inert tablet p.o., 60-90 min prior to estimated induction time