CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 687 enrolled
Drug / intervention
Vitamin B12 and folic acid +2 moredrug
Likely dose
Vitamin B12 and folic acid 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00655980
NCT00655980N/ACompleted
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Pharmacogenetics of Adverse Outcomes After Nitrous Oxide Anesthesia

Washington University School of Medicine·interventional·Posted Apr 10, 2008·Updated Oct 1, 2020

In Brief

A clinical study evaluating Vitamin B12 and folic acid, Nitrous oxide and placebo, and 1 other intervention for Major Surgery and Coronary Artery Disease. Completed, enrolled 687 participants across 1 site.

Detailed Summary

In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be prevented by giving patients vitamin B12 and folate during surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Surgery, Coronary Artery Disease
CountriesUnited States
CollaboratorsNational Institute of General Medical Sciences (NIGMS), Foundation for Anesthesia Education and Research

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 10, 2008
Enrollment StartFeb 1, 2008
Primary CompletionDec 1, 2016
TodayJul 2, 2026
Enrollment to primary: 8.8 yearsPosted 18.2 years ago

Interventions

Vitamin B12 and folic aciddrug

1 mg vitamin B12 IV 5 mg folic acid IV in 100 ml NS infusion

Nitrous oxide and placebodrug

standard of careother