At a glance
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High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia in Parkinson Disease
In Brief
A clinical study evaluating Resistance Exercise via Negative Eccentric Work and Standard care exercise training for Parkinson Disease. Completed, enrolled 41 participants across 1 site.
Detailed Summary
Parkinson disease is a degenerative neurologic condition characterized by slowness of movement, tremor, and loss of balance control. It results in significant degrees of disability for affected individuals. Exercise and medication management are two treatments frequently used to treat Parkinson disease, and although some individuals benefit from these treatments, by what effect exercise works is presently not known. We will examine muscle structure and movement control responses to strengthening exercises and compare them to the therapeutic response observed as a result of medication intake. This process will allow us to better understand the mechanisms underlying the therapeutic effects of strengthening exercise for persons with Parkinson disease.
Study Details
Timeline
Interventions
High intensity resistance training delivered 2-3 times per week for 12 weeks
Evidence based exercise training (resistance training, aerobic training, flexibility training) 2-3 times per week for 12 weeks.