At a glance
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Rescue Antenatal Steroids and Lung Volumes in Preterm Infants
In Brief
A clinical study evaluating betamethasone and placebo for Respiratory Compliance and 2 related conditions. Completed, enrolled 85 participants across 1 site.
Detailed Summary
One course of steroids given to a mother before a premature delivery helps the lungs of the premature infant and decreases breathing problems. One course of antenatal steroids is the standard of care for threatened premature deliveries. It is unclear as to how long the benefit of one course of steroids last. The most benefit to the baby's lungs seem to occur if the steroids are given at least 24 hours before but within 7 days of a premature delivery. It is difficult to predict the timing of a preterm delivery so deliveries often do not occur within this time period. We hypothesize that the benefits of the steroids to the lungs wear off if the steroids are given more than 14 days before a preterm delivery, and that in these circumstances an extra course of steroids will help the premature baby's lungs and the premature baby will have less breathing problems as shown by lung function testing.
Study Details
Timeline
Interventions
12 mg IM q 24 hours x 2 doses
Placebo IM q 24 hours x 2 doses