At a glance
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Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence
In Brief
A clinical study evaluating Smoking Abstinence for Smoking. Completed, enrolled 62 participants across 1 site.
Detailed Summary
The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in response inhibition during smoking abstinence. We will measure changes in performance and regional blood oxygenation levels using functional magnetic resonance imaging (fMRI)while smokers complete tasks designed to assess decision making and response inhibition. Our primary hypothesis is that smoking abstinence will result in impaired response inhibition accompanied by decreases in blood-oxygenation-level-dependent (BOLD) fMRI signal in brain regions associated with these cognitive processes including frontal cortex and the ventral striatum. Abstinence may also result in performance-related increases in activation in brain regions associated with effortful processing including the anterior cingulate cortex in effort to compensate for deficits in other regions.
Study Details
Timeline
Interventions
Smokers were scanned after having quitting smoking for 24 hours, and scanned after smoking as usual.