At a glance
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Heritability of Opioid Effects: A Twin Study
In Brief
A clinical study evaluating Alfentanil and Saline placebo infusion for Pain. Completed, enrolled 242 participants across 1 site.
Detailed Summary
Proposed twin study will test to what degree inter-individual differences in pain sensitivity and amount of pain relief in response to opioid therapy are inherited or alternatively, are due to environmental factors. This knowledge is important to guide future studies trying to explain such inter-individual differences. For example, finding that differences are largely due to environmental factors would discourage genomic studies and emphasize epidemiological studies.
Study Details
Timeline
Interventions
Target controlled intravenous infusion of alfentanil at a plasma concentration of 100ng/ml
Intravenous infusion of normal saline