CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 537 enrolled
Drug / intervention
Nebivolol with concomitant losartan or lisinopril +2 moredrug
Likely dose
Nebivolol with concomitant losartan or lisinopril 5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00673790
NCT00673790Phase 4Completed
CompareCT.gov

Blood Pressure and Metabolic Effects of Nebivolol Compared With Hydrochlorothiazide and Placebo in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose

Forest Laboratories·interventional·Posted May 7, 2008·Updated Feb 26, 2020

In Brief

A Phase 4 clinical trial evaluating Nebivolol with concomitant losartan or lisinopril, HCTZ with concomitant losartan or lisinopril, and 1 other intervention for Hypertension. Completed, enrolled 537 participants across 88 sites.

Detailed Summary

This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hypertensive patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 7, 2008
Enrollment StartMay 15, 2008
Primary CompletionJul 9, 2010
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 18.2 years ago

Interventions

Nebivolol with concomitant losartan or lisinoprildrug

Encapsulated Nebivolol 5 mg, 10 mg, 20, mg, 40 mg total daily dosage, oral administration with concomitant treatment consisting of lisinopril 10 mg total daily dosage, oral administration or losartan 50 mg total daily dosage, oral administration.

HCTZ with concomitant losartan or lisinoprildrug

Encapsulated Hydrochlorothiazide 12.5 mg or 25 mg total daily dosage, oral administration with concomitant treatment consisting of lisinopril 10 mg total daily dosage, oral administration or losartan 50 mg total daily dosage, oral administration.

Placebo with concomitant losartan or lisinoprildrug

Placebo with concomitant treatment consisting of lisinopril 10 mg total daily dosage, oral administration or losartan 50 mg total daily dosage, oral administration.