At a glance
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A Double-blind Randomised, Placebo-controlled Study of Adjunctive Ketamine Anaesthesia in ECT (Electroconvulsive Therapy)
In Brief
A Phase 4 clinical trial evaluating Ketamine and Saline for Major Depressive Episode. Completed, enrolled 83 participants across 1 site.
Detailed Summary
Research into the mechanisms underlying memory impairment in ECT suggests that its development may be prevented by the administration of certain medications at the time of ECT treatment. For example there are reasons to believe that ketamine, also used as an anaesthetic agent, may have such protective properties. In this clinical study patients undergoing a course of ECT will be offered the opportunity to receive a small dose of ketamine (or a placebo) as part of their anaesthetic at the time of ECT treatment. Mood changes and any memory changes will be evaluated to see if the subjects who received ketamine had less memory side effects than those who did not, while still improving their depression.
Study Details
Timeline
Interventions
Ketamine IV will be administered after the administration of the normal anaesthetic agents for ECT.
Saline (placebo) will be administered after the normal anaesthetic agents in ECT.