CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 94 enrolled
Drug / intervention
CK-1827452 24mg and 6 mg iv infusion +5 moredrug
Likely dose
CK-1827452 24mg and 6 mg iv infusionfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00682565
NCT00682565Phase 2Completed
CompareCT.gov

Tolerability and CK-1827452 Plasma Concentrations During Intravenous and Immediate-Release Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina

Cytokinetics·interventional·Posted May 22, 2008·Updated Aug 21, 2018

In Brief

A Phase 2 clinical trial evaluating CK-1827452 24mg and 6 mg iv infusion, CK-1827452 12.5mg capsule, and 4 other interventions for Heart Failure and 2 related conditions. Completed, enrolled 94 participants across 14 sites in 2 countries.

Detailed Summary

This study investigates whether symptom-limited exercise capacity in ischemic cardiomyopathy patients with angina is deleteriously affected by treatment with CK-1827452.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Failure, Myocardial Ischemia, Angina Pectoris
CountriesGeorgia, Russia
Collaborators--

Timeline

Phase 2CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 22, 2008
Enrollment StartApr 1, 2008
Primary CompletionNov 1, 2008
Study CompletionMar 1, 2009
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 18.1 years ago

Interventions

CK-1827452 24mg and 6 mg iv infusiondrug

I.V. infusion for 2 hours at 24mg/hr followed by 18 hours at 6mg/hr

CK-1827452 12.5mg capsuledrug

12.5mg oral immediate release capsule

CK-1827452 48 mg and 11 mg iv infusiondrug

I.V. infusion for 2 hours at 48mg/hr followed by 18 hours at 11mg/hr

CK-1827452 25mg capsuledrug

25mg oral immediate release capsule

Placebo iv infusiondrug

Matching placebo iv infusion

Placebo capsuledrug

Matching placebo oral immediate release capsule