At a glance
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Clinical Trial of Topiramate for Cocaine Addiction
In Brief
A Phase 2 clinical trial evaluating topiramate, Contingency Reinforcement, and 1 other intervention for Cocaine Dependence. Completed, enrolled 250 participants across 1 site.
Detailed Summary
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment. The study aims to answer whether topiramate 1. is safe and acceptable to methadone patients 2. reduces cocaine use 3. helps with collateral problems such as alcohol abuse, tobacco dependence, anxiety, PTSD and/or pain symptoms. The study will also evaluate topiramate effect on neuro-cognitive performance.
Study Details
Timeline
Interventions
topiramate powder 0mg - 150 mg with lactate in blind capsules. Two capsules dispensed daily. One capsule ingested under supervision at the methadone window. One capsule to be ingested at home at bedtime. Participant is expected to return the empty blister pack on the following day. capsules are administered from week 4 through 25 of the trial
monetary reward for self-reported cocaine abstinence confirmed by urine toxicology results
participant receives placebo capsules and monetary reinforcers by chance, irrespective of cocaine use or abstinence