At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter
In Brief
A Phase 1 clinical trial evaluating Nitroglycerin 15mg, Nitroglycerin 30mg, and 3 other interventions for Healthy. Completed, enrolled 19 participants across 1 site.
Detailed Summary
The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply. In order to facilitate successful catheterization of the artery, a dilated artery and one free of arterial spasm is desirable. The proposed study will randomize twenty three healthy subjects in 2 visits to determine the effect of topical nitroglycerin on radial artery vasodilation. Radial artery diameter will be measured with ultrasound at regular intervals up to two hours.
Study Details
Timeline
Interventions
15mg Nitroglycerin applied topically to one wrist
30mg Nitroglycerin applied topically to one wrist
20mg Lidocaine applied topically to one wrist in combination with nitroglycerin or placebo
40mg Lidocaine applied topically to one wrist in combination with nitroglycerin or placebo
Topical skin moisturizing cream with same appearance as active agent