CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 41 enrolled
Drug / intervention
Ziv-Aflibercept +4 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00729157
NCT00729157Phase 2Completed
CompareCT.gov

A Phase II Study of Single Agent Intravenous (IV) VEGF Trap in Patients With Poor Prognostic Recurrent and/or Metastatic Thyroid Cancer After RAI Therapy

National Cancer Institute (NCI)·interventional·Posted Aug 7, 2008·Updated Mar 15, 2017

In Brief

A Phase 2 clinical trial evaluating Fludeoxyglucose F-18, Laboratory Biomarker Analysis, and 3 other interventions for Recurrent Thyroid Gland Carcinoma and 4 related conditions. Completed, enrolled 41 participants across 1 site.

Detailed Summary

This phase II trial is studying how well aflibercept works in treating patients with recurrent and/or metastatic thyroid cancer that has not responded to radioactive iodine therapy. Aflibercept may stop the growth of tumor cells by blocking blood flow to the tumor and by carrying tumor-killing substances directly to thyroid cancer cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsRecurrent Thyroid Gland Carcinoma, Stage III Thyroid Gland Follicular Carcinoma, Stage III Thyroid Gland Papillary Carcinoma, Stage IV Thyroid Gland Follicular Carcinoma, Stage IV Thyroid Gland Papillary Carcinoma
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 7, 2008
Enrollment StartAug 1, 2008
Primary CompletionOct 1, 2012
Study CompletionNov 1, 2012
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 17.9 years ago

Interventions

Fludeoxyglucose F-18radiation

Correlative studies

Laboratory Biomarker Analysisother

Correlative studies

Pharmacological Studyother

Correlative studies

Positron Emission Tomographyprocedure

Correlative studies

Ziv-Afliberceptbiological

Given IV