CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 300 enrolled
Drug / intervention
Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00729794
NCT00729794Phase 3Completed
CompareCT.gov

Vasopressin, Epinephrine, and Corticosteroids for Inhospital Cardiac Arrest: A Multicenter Randomized Controlled Trial

University of Athens·interventional·Posted Aug 8, 2008·Updated Nov 21, 2016

In Brief

A Phase 3 clinical trial evaluating Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisone and Standard CPR Protocol with Epinephrine and two Placebos for Cardiac Arrest. Completed, enrolled 300 participants across 3 sites.

Detailed Summary

The simultaneous activation of adrenergic and vasopressin receptors, in conjunction with a potential steroid-mediated enhancement of the vascular reactivity to epinephrine may have beneficial effects in patients with cardiac arrest. This hypothesis is supported by the single-center results of NCT 00411879. The investigators intend to either refute or provide definitive evidence supporting this hypothesis (and its generalizability) by conducting the present multicenter, randomized, controlled clinical trial of in hospital cardiac arrest.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiac Arrest
CountriesGreece
CollaboratorsUniversity of Thessaly

Timeline

Phase 3CompletedFinished
2009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 8, 2008
Enrollment StartSep 1, 2008
Primary CompletionNov 1, 2010
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 17.9 years ago

Interventions

Vasopressin, Epinephrine, Methylprednisolone, Hydrocortisonedrug

Combination Treatment Administration of vasopressin, epinephrine, and methylprednisolone during CPR, and of stress dose hydrocortisone after CPR

Standard CPR Protocol with Epinephrine and two Placebosdrug

Patients receive advanced life support according to the Guidelines for Resuscitation 2005