At a glance
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Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure
In Brief
A clinical study evaluating Europe: AutoSet CS (USA: VPAP Adapt SV) for Heart Failure and Sleep Disordered Breathing. Completed, enrolled 1,325 participants across 267 sites in 11 countries.
Detailed Summary
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic dysfunction, already receiving optimal medical therapy, who have sleep disordered breathing (SDB) that is predominantly central sleep apnea. Assumptions: the intervention reduces the hazard rate by 20%. The event rate in the control group is 35% in the first year. It is assumed that the hazard rate is constant over time.
Study Details
Timeline
Interventions
At least 3 hours average daily usage time