CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 115 enrolled
Drug / intervention
Aprepitant + Dexamethasone +1 moredrug
Likely dose
Aprepitant + Dexamethasone 40 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00734929
NCT00734929Phase 4Completed
CompareCT.gov

A Comparison of the Combination of Aprepitant and Dexamethasone Versus the Combination of Ondansetron and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Craniotomy

Duke University·interventional·Posted Aug 14, 2008·Updated Mar 13, 2017

In Brief

A Phase 4 clinical trial evaluating Aprepitant + Dexamethasone and Ondansetron + Dexamethasone for Postoperative Nausea and Vomiting. Completed, enrolled 115 participants across 1 site.

Detailed Summary

We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in patients undergoing craniotomy under general anesthesia.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Nausea and Vomiting
CountriesUnited States
CollaboratorsMerck Sharp & Dohme LLC

Timeline

Phase 4CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 14, 2008
Enrollment StartSep 1, 2007
Primary CompletionJun 1, 2009
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 17.9 years ago

Interventions

Aprepitant + Dexamethasonedrug

Aprepitant 40 mg + Dexamethasone 10 mg

Ondansetron + Dexamethasonedrug

Ondansetron 4 mg + Dexamethasone 10 mg