CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 227 enrolled
Drug / intervention
Linagliptin +2 moredrug
Likely dose
Linagliptin 5mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00740051
NCT00740051Phase 3Completed

A Randomised, db, Placebo-controlled, Parallel Group Efficacy and Safety Study of BI 1356 (5mg), Administered Orally Once Daily for 18 Weeks Followed by a 34 Week Double-blind Extension Period (Placebo Patients Switched to Glimepiride) in Type 2 Diabetic Patients With Insufficient Glycaemic Control for Whom Metformin Therapy is Inappropriate (Intolerability or Contraindication)

Boehringer Ingelheim·interventional·Posted Aug 22, 2008·Updated Jun 27, 2014

In Brief

A Phase 3 clinical trial evaluating Linagliptin, Linagliptin Placebo, and 1 other intervention for Diabetes Mellitus, Type 2. Completed, enrolled 227 participants across 53 sites in 7 countries.

Detailed Summary

Efficacy of BI 1356 compared to placebo in patients for whom metformin therapy is inappropriate (intolerability, contraindication). The second part of the study looks at the safety of BI 1356 in this patient population with longer term treatment in comparison to a sulfonylurea drug (glimepiride)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Mexico, Philippines, Romania, Russia, Ukraine, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 22, 2008
Enrollment StartAug 1, 2008
Primary CompletionAug 1, 2010
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 17.9 years ago

Interventions

Linagliptindrug

5mg once daily

Linagliptin Placebodrug

0 mg placebo comparator for part 1 of study (to 18 weeks)

Glimepiridedrug

1-4mg for part 2 of study (weeks 19-52)