At a glance
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A Double-blind, Placebo-controlled, Crossover Study Examining the Acute Effects of Olanzapine on Plasma Leptin, Glucose Tolerance and Free Fatty Acids in Healthy Volunteers
In Brief
A clinical study evaluating Olanzapine 10 mg po qhs for 3 days and Placebo for Insulin Resistance and Diabetes Mellitus. Completed, enrolled 15 participants across 1 site.
Detailed Summary
The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2) rapidly alters glucose tolerance in healthy volunteers. These questions will be answered by having volunteers undergo two glucose tolerance tests in a crossover study design.
Study Details
Timeline
Interventions
(1) 10 mg tablets administered orally before bed for three consecutive evenings (Total Dose = 30 mg, 3 tablets)
(1) placebo tablets administered orally before bed for three consecutive evenings (Total Dose = 3 tablets)