CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 34 enrolled
Drug / intervention
Placebo capsules +5 moredrug
Likely dose
Low dose Dronabinol 10mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00743119
NCT00743119Phase 2Completed
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Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers

New York State Psychiatric Institute·interventional·Posted Aug 28, 2008·Updated Dec 11, 2017

In Brief

A Phase 2 clinical trial evaluating Placebo capsules, Inactive marijuana (0% THC), and 4 other interventions for Pain Threshold and Mood. Completed, enrolled 34 participants across 1 site.

Detailed Summary

The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive validity for clinical use of analgesics. Oral THC (dronabinol) is known to have a slower onset and longer duration of action compared with smoked marijuana. Therefore, the analgesic effects of oral THC is expected to peak later and last longer than effects produced by smoked marijuana.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain Threshold, Mood
CountriesUnited States
CollaboratorsResearch Foundation for Mental Hygiene, Inc., National Institute on Drug Abuse (NIDA)

Timeline

Phase 2CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 28, 2008
Enrollment StartJun 1, 2008
Primary CompletionOct 1, 2009
Study CompletionMay 1, 2013
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 17.8 years ago

Interventions

Placebo capsulesdrug

Placebo capsules

Inactive marijuana (0% THC)drug

Inactive marijuana cigarettes (0% THC) provided by NIDA

Low dose Dronabinoldrug

Dronabinol 10mg

High dose Dronabinoldrug

Dronabinol 20mg

Low THC marijuanadrug

marijuana cigarettes (1.98% THC) provided by NIDA

High THC marijuanadrug

Marijuana cigarettes (3.56% THC) provided by NIDA