At a glance
ClinicalIndex Comparison RecordN/ACompleted· 15 enrolled
Drug / intervention
Endothelin-1 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
In Brief
A clinical study evaluating Endothelin-1 and BQ-123 and BQ-788 for Coronary Disease. Completed, enrolled 15 participants across 1 site.
Detailed Summary
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Disease
CountriesSweden
CollaboratorsUmeå University
Timeline
N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartMar 2008
Primary CompletionMay 2008
First PostedSep 2008
TodayJul 2026
First PostedSep 3, 2008
Enrollment StartMar 1, 2008
Primary CompletionMay 1, 2008
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 17.8 years ago
Interventions
Endothelin-1drug
Intra-arterial infusion of Endothelin-1 at 5pmol/min for 1 hour during venous occlusion plethysmography
BQ-123 and BQ-788drug
1 hour intra-arterial infusion of BQ-123 at 10nmol/min followed by co-infusion of BQ-788 at 1nmol/min for a further hour during forearm venous occlusion plethysmography