At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Increased Short Chain Fatty Acids in the Colon Are Associated With Improved Energy Homeostasis and Insulin Sensitivity.
In Brief
A clinical study evaluating Propionate ester, Inulin, and 1 other intervention for Obesity. Completed, enrolled 60 participants across 1 site.
Detailed Summary
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel. SCFA are thought to have direct beneficial effects on the gut, appetite, weight and fat distribution. This study will look into these effects by conducting a dose finding study and then a randomised controlled study using healthy human volunteers.
Study Details
Timeline
Interventions
The subject will take propionate ester at the dose specified by the dose finding study, three times a day for 24 weeks
The subjects in this group will take inulin at a comparable dose, three times a day for 24 weeks
The subjects in this group will take the non fermentable carbohydrate, cellulose, at a comparable dose for 24 weeks.