At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Comparison of the Effect of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
In Brief
A clinical study evaluating Metoprolol, Esmolol, and 1 other intervention for Myocardial Ischemia. Completed, enrolled 60 participants across 1 site.
Detailed Summary
We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups. Our hypothesis is that the metoprolol and esmolol groups will require a lower level of anesthetic agent to achieve the targeted BIS range, compared to the placebo group. Our objective is to clarify if metoprolol, in a dose range used for perioperative cardiac protection, decreases anesthetic requirement.
Study Details
Timeline
Interventions
60ml syringes of 0.9% NaCl, 5ml syringes of metoprolol at 1mg/ml concentration
60ml syringes of esmolol at 10 mg/ml concentration, 5ml syringes of 0.9% of NaCl
0.9%NaCl dispensed in 60ml \& 5ml syringes