CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 39 enrolled
Drug / intervention
Memantine (Namenda®) +1 moredrug
Likely dose
Memantine (Namenda®) 5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00768261
NCT00768261Phase 4Completed
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Corticolimbic Degeneration and Treatment of Dementia

Washington University School of Medicine·interventional·Posted Oct 8, 2008·Updated Sep 11, 2018

In Brief

A Phase 4 clinical trial evaluating Memantine (Namenda®) and Donepezil (Aricept®) for Dementia. Completed, enrolled 39 participants.

Detailed Summary

The overall purpose of this research is to determine if there is a relationship between your symptoms of Dementia of the Alzheimers type and changes in the size and shape of certain brain structures during combined Donepezil (Aricept®) and Memantine (Namenda®) treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDementia
Countries--
CollaboratorsNorthwestern University

Timeline

Phase 4CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 8, 2008
Enrollment StartNov 1, 2004
Primary CompletionOct 1, 2009
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 17.7 years ago

Interventions

Memantine (Namenda®)drug

Drug treatment will begin with 5 mg/day of donepezil for six weeks. After six weeks of such treatment, the subjects symptoms will be re-evaluated and any side-effects of treatment assessed and recorded. If no serious side-effects of donepezil are encountered, the dose of donepezil will be increased to 10 mg/day. For subjects prescribed the combination of donepezil and memantine, memantine (20 mg/day) will be added to the drug treatment regimen after the dose of donepezil has been established (i.e., at six weeks). Again, memantine will be initially started at 10 mg/day and increased to its full dose only if no serious side-effects are encountered.

Donepezil (Aricept®)drug

5mg/day for six weeks and if no serious side-effects increased to 10mg/dy.