CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 19 enrolled
Drug / intervention
PET (Positron Emission Tomography) +4 moreprocedure
Likely dose
Not stated in record
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Search/NCT00776035
NCT00776035N/ACompleted
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Sex and Obesity Effects on Myocardial Blood Flow and Metabolism

Washington University School of Medicine·observational·Posted Oct 20, 2008·Updated May 3, 2024

In Brief

An observational study evaluating PET (Positron Emission Tomography), Echocardiogram, and 3 other interventions for Obesity and Heart Failure. Completed, enrolled 19 participants across 1 site.

Detailed Summary

Sex has a major impact on myocardial metabolism and blood flow. In those without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow. Obesity is a major risk factor for Heart Failure. In those without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men. To measure blood flow and metabolism we used radioactive materials and a PET (positron emission Tomography) scan to study the blood flow and substrate metabolism of the heart. Hypotheses: 1) Women with heart failure with reduced ejection fraction (HFrEF) will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with HFrEF. A secondary Aim was to test the hypothesis that body mass index (BMI), a measure of obesity, correlated with myocardial blood flow and myocardial metabolism measures in patients with HFrEF.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsObesity, Heart Failure
CountriesUnited States
CollaboratorsThe Foundation for Barnes-Jewish Hospital

Timeline

N/ACompletedFinished
2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 20, 2008
Enrollment StartFeb 1, 2000
Primary CompletionApr 2, 2011
TodayJul 2, 2026
Enrollment to primary: 11.2 yearsPosted 17.7 years ago

Interventions

PET (Positron Emission Tomography)procedure

This is a diagnostic scan that requires the injection of radioactive tracer compounds intravenously using an IV placed in the arm.

Echocardiogramprocedure

An echocardiogram is an ultrasound of the heart. Participants received a complete 2D- and Doppler echocardiographic examination on the day of the PET scan.

^15O-waterradiation

This is a radioactive tracer used to study blood flow in the heart during the PET scan. It was administered intravenously at a dose of 20 mCi.

1-^11C-palmitateradiation

This is a radioactive tracer used to study fatty acid usage in the heart during the PET scan. It was administered intravenously at a dose of 20 mCi.

1-^11C-glucoseradiation

This is a radioactive tracer used to study glucose usage in the heart during the PET scan. It was administered intravenously at a dose of 20 Mci..