At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Training Effects on Skeletal Muscle Fatty Acid Metabolism
In Brief
A clinical study evaluating 20% lipid infusion and glycerol for Healthy Volunteers. Completed, enrolled 33 participants across 1 site.
Detailed Summary
We are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. We know that if pharmaceutical grade fat is infused into people, they develop insulin resistance. Likewise, we would like to infuse pharmaceutical grade fat into trained subjects, believing that trained subjects will have less insulin resistance, less decline in muscle energy function, and less accumulation of fat metabolites than untrained subjects. For comparing the effects of the pharmaceutical grade fat infusion, we will also have a group of trained and untrained subjects given a control (glycerol) infusion. Glycerol is basically the same as pharmaceutical grade fat infusion without the fat component.
Study Details
Timeline
Interventions
1.5 ml/min for 6 hours
glycerol infusion (2.25 g/100ml) will be administered at 1.5 ml/min,