At a glance
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Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease
In Brief
A Phase 2 clinical trial evaluating Hematopoietic Stem Cell Transplantation, Cyclophosphamide, and 5 other interventions for Devic's Disease. Completed, enrolled 13 participants across 1 site.
Detailed Summary
This study is designed to examine whether treating Devic's disease patients with high dose cyclophosphamide together with rabbit antithymocyte globulin (rATG)/rituximab (drugs which reduce the function of the immune system), followed by return of previously collected patient's stem cells will result in improvement in Devic's disease. Stem cells are undeveloped cells that have the capacity to grow into mature blood cells, which normally circulate in the blood stream. The purpose of the intense chemotherapy is to destroy the cells in patient's immune system, which may be causing his/her disease. The purpose of the stem cell infusion is to produce a normal immune system that will no longer attack patient's body. The purpose of study is to examine the safety and efficacy of this treatment. The drugs used in this study treatment are drugs for commonly used for immune suppression.
Study Details
Timeline
Interventions
Infusion of participant's own stem cells
A medication used as chemotherapy and to suppress the immune system
A glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream
A rabbit polyclonal antibody to lymphocytes
A medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder
Monoclonal antibody therapy used to treat certain autoimmune diseases and types of cancer
A corticosteroid medication used to suppress the immune system and decrease inflammation