At a glance
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Effects of Short-term Growth Hormone in HIV-infected Patients
In Brief
A clinical study evaluating Growth hormone and Growth Hormone Releasing Hormone for HIV Lipodystrophy. Completed, enrolled 25 participants across 1 site.
Detailed Summary
The purpose of this study is to examine the short-term effects of two different doses of growth hormone, compared to treatment with growth hormone releasing hormone, on the brain's secretion of growth hormone and the body's glucose metabolism. We hypothesize that growth hormone administration will alter the body's endogenous pulsatile growth hormone secretion and that higher dose growth hormone may decrease insulin sensitivity. We hypothesize that growth hormone releasing hormone will augment endogenous GH pulsatility and be neutral to insulin sensitivity.
Study Details
Timeline
Interventions
Recombinant Human Growth Hormone (Teva pharmaceuticals), with one arm receiving 6mcg/kg SC once daily for two weeks and the other arm receiving 2mg SC once daily for two weeks
Tesamorelin (GHRH) 2mg SC QD x 2 weeks