CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 35 enrolled
Drug / intervention
Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension +1 moredrug
Likely dose
Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspensionfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00800540
NCT00800540Phase 4Completed
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Effects of Topical Hypotensive Drugs on Circadian Ocular Perfusion Pressure and Ocular Blood Flow in Patients With Open-Angle Glaucoma

Alcon Research·interventional·Posted Dec 2, 2008·Updated Mar 22, 2013

In Brief

A Phase 4 clinical trial evaluating Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension and Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solution for Glaucoma. Completed, enrolled 35 participants across 1 site.

Detailed Summary

The purpose of this study was to compare the short term effects of two intraocular pressure (IOP) lowering medications on ocular perfusion pressure (OPP), ocular blood flow, intraocular pressure, and blood pressure in patients with glaucoma. Ocular perfusion pressure (OPP) is defined as the difference between arterial blood pressure (diastolic and systolic) and intraocular pressure. The primary efficacy assessment is based on diastolic ocular perfusion pressure.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGlaucoma
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 2, 2008
Enrollment StartFeb 1, 2009
Primary CompletionJan 1, 2012
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 17.6 years ago

Interventions

Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspensiondrug

Fixed combination ophthalmic suspension

Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solutiondrug

Fixed combination ophthalmic solution