At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Dopamine Receptor Availability and Insulin Resistance
In Brief
A clinical study evaluating PET scan, Oral glucose tolerance test, and 3 other interventions for Obesity. Completed, enrolled 28 participants across 1 site.
Detailed Summary
Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure.Obesity is also associated with insulin resistance (poor insulin action).We propose that insulin resistance and low DRD2 are associated. Using PET imaging,we aim to determine DRD2 binding potential (BP) in the brain is associated with insulin resistance and neuroendocrine hormone levels. Obese participants will be compared to lean, gender and age similar participants. We also aim to determine the effect of caloric restriction on DRD2 BP in obese subjects
Study Details
Timeline
Interventions
Both lean and obese undergo a PET scan of the brain using the radioligand,fallypride \[18F\] at baseline. Obese subjects who complete caloric restriction will have repeat scan after diet. Completed at baseline and post-VLCD
Subjects will be required to drink a glucose solution; blood samples will be taken over a 5-hour time period Completed at baseline by both lean and obese and in obese post-VLCD
An MRI of the brain and abdomen will be performed prior to PET scan One time at baseline in both lean and obese
A series of short psychological scales will be administered during the study. Completed at baseline
Obese participants only complete a short-term (\~10days) very low calorie diet