At a glance
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A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/Carboplatin Chemotherapy in Patients With High Risk, Early Stage Endometrial Carcinoma
In Brief
A Phase 3 clinical trial evaluating 3-Dimensional Conformal Radiation Therapy, Carboplatin, and 6 other interventions for Endometrial Clear Cell Adenocarcinoma and 6 related conditions. Targeting 601 participants across 540 sites in 2 countries.
Detailed Summary
This randomized phase III trial studies pelvic radiation therapy to see how well it works compared with vaginal implant radiation therapy, paclitaxel, and carboplatin in treating patients with high-risk stage I or stage II endometrial cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Implant radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether pelvic radiation therapy alone is more effective than vaginal implant radiation therapy, paclitaxel, and carboplatin in treating patients with endometrial cancer.
Study Details
Timeline
Interventions
Undergo pelvic radiation therapy
Given IV
Undergo pelvic radiation therapy
Undergo vaginal cuff brachytherapy
Correlative studies
Given IV
Ancillary studies
Ancillary studies