At a glance
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A Controlled Clinical Trial on The Use of a Specific Antivenom Against Envenoming by Bungarus Multicinctus
In Brief
A Phase 2 clinical trial evaluating Bungarus multicinctus-candidus Antivenom and Supportive Care for Snake Bite. Completed, enrolled 81 participants across 1 site.
Detailed Summary
In northern Vietnam, a vast majority of the most severe envenomed patients are bitten by Bungarus multicinctus. Hitherto, these victims have received supportive care only. The aims of this study were to assess the possible efficacy and side effects of a newly produced antivenom.
Study Details
Timeline
Interventions
Five to ten ampoules of antivenom, depending on severity of muscle paralysis, were diluted with isotonic glucose solution to have total 50 ml and infused intravenously by electric pump during one hour. After a period of 6-8 hours, a second infusion was administered, under similar condition to the first, if no clinical improvement or adverse reaction had been noted. The patients also received supportive care such as intubation, ventilation...if necessary.
Supportive Care only (endotracheal intubation, mechanical ventilation...)