At a glance
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QEEG Predictors of Response for Psychotherapy Compared to Pharmacotherapy in Depression
In Brief
A Phase 4 clinical trial evaluating Cognitive Behavioral Therapy (CBT) and Escitalopram for Major Depressive Disorder. Completed, enrolled 39 participants across 1 site.
Detailed Summary
The purpose of this research study is to find out if a test can predict whether someone with depression will get better with treatment. We also want to find out whether there are changes in the brains of depressed patients having different types of treatment (drug therapy vs. talk therapy). We hope that a test called QEEG (Quantitative Electroencephalogram) can tell us if a treatment is going to work, even before the person starts to feel better. Hypothesis 1: Response to treatment will correlate with changes in QEEG metrics. Hypothesis 2: QEEG parameters, different from those that predict response to pharmacotherapy, will be associated with response to CBT.
Study Details
Timeline
Interventions
The CBT group will receive weekly 50-minute individual sessions over the course of 12 weeks conducted by experienced therapists who are trained in manual based CBT.
The medication group will receive open label treatment of escitalopram, 10-20 mg/day, flexible dose, for 12 weeks, and will be seen every two weeks by a study physician.