At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of High Dose Citric on PPI (Proton Pump Inhibitors)Induced False Negative H. Pylori UBT Rates
In Brief
A Phase 4 clinical trial evaluating Lansoprazole (Lanton), Omeprezole (Losec), and 2 other interventions for Helicobacter Pylori Infection. Completed, enrolled 123 participants across 1 site.
Detailed Summary
Approximately 200 patients with suspected H.pylori will be tested with a 13C-Urea Breath Test (UBT) to ascertain H.pylori positive. 100 H.Pylori positive patients will tested before and after prescribed with one of the four selected Proton Pump Inhibitors (PPIs); 25 patients in each arm. This will provide information on the influence of PPIs on the UBT (Urea Breath Test). The aim of the trial is to observe the effect of different PPIs on the breath test and choose the optimal protocol of when to stop PPI. The hypothesis is that there will be a minimal effect on the UBT while using selected PPIs.
Study Details
Timeline
Interventions
Oral administration of Lanzoprazole for 14 days in 25 patients with H.pylori infection
Oral administration of Omeprazole for 14 days in 25 patients with H.pylori infection
Oral administration of Pantoprazole for 14 days in 25 patients with H.pylori infection
Oral administration of Esomeprazole for 14 days in 25 patients with H.pylori infection