CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 206 enrolled
Drug / intervention
Sertraline +1 moredrug
Likely dose
Sertraline 50 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00834652
NCT00834652Phase 4Completed
CompareCT.gov

Improving Depression Treatment Outcomes With an Insulin-Sensitizing Agent

Washington University School of Medicine·interventional·Posted Feb 3, 2009·Updated Sep 10, 2018

In Brief

A Phase 4 clinical trial evaluating Sertraline and Metformin for Depression. Completed, enrolled 206 participants across 1 site.

Detailed Summary

This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 4CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 3, 2009
Enrollment StartSep 1, 2007
Primary CompletionMay 1, 2013
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 17.4 years ago

Interventions

Sertralinedrug

50 mg once a day, which may be increased to 200 mg once a day

Metformindrug

Starting dose of 500 mg daily and increasing by 500 mg every 2 weeks to a total of 2,000 mg daily