At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia
In Brief
A Phase 2 clinical trial evaluating L-NAME, Midodrine, and 1 other intervention for Orthostatic Hypotension and Spinal Cord Injury. Completed, enrolled 34 participants across 1 site.
Detailed Summary
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day in persons with spinal cord injury.
Study Details
Timeline
Interventions
A non-selective inhibitor of nitric oxide synthase and placebo. It has been used experimentally to induce hypertension.
To treat low blood pressure.
A pill with an inactive substance that looks like the study drug.