CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 89 enrolled
Drug / intervention
Nesiritide +1 moredrug
Likely dose
Nesiritide 2 mcg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00842023
NCT00842023Phase 4Completed

A Randomized Controlled Trial to Evaluate Renal Function, Inflammatory Mediators, and Neurohormonal Markers in Acutely Decompensated Heart Failure Patients Receiving Nesiritide Compared to Nitroglycerin.

Western University of Health Sciences·interventional·Posted Feb 12, 2009·Updated Aug 30, 2013

In Brief

A Phase 4 clinical trial evaluating Nesiritide and Nitroglycerin for Acute Decompensated Heart Failure. Completed, enrolled 89 participants across 1 site.

Detailed Summary

The purpose of this study is to determine whether Nesiritide is more effective than nitroglycerin in modifying inflammatory and neurohormonal biomarkers without renal toxicity when proper infusion duration is administered.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 4CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 12, 2009
Enrollment StartJul 1, 2006
Primary CompletionJul 1, 2008
Study CompletionFeb 1, 2009
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 17.4 years ago

Interventions

Nesiritidedrug

Bolus 2 mcg/kg followed by 0.01 mcg/kg/min

Nitroglycerindrug

5-10 mcg/min titrating per protocol based on blood pressure