At a glance
ClinicalIndex Comparison Record- ✓Age 35-50 years (middle-age group) or 65-80 years (elderly group)
- ✓Weight stable (<5% variation) in last 3 months
- ✓BMI 20-29.9 kg/m²
- ✓Normal glucose tolerance
- ✕Use of estrogen, progestogen, or systemic corticosteroids
- ✕Hepatic cirrhosis or renal failure
- ✕Smoking
- ✕Obesity
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly.
In Brief
An observational study for Diabetes Mellitus, Type 2 and Insulin Resistance. Completed, enrolled 24 participants across 1 site.
Detailed Summary
Like most endocrine axes, the entero-insular axis is expected to go through an age-related physiological deterioration, what might contribute to special features of the elderly onset type 2 diabetes in comparison to middle-age. Twenty four NGT volunteers will be evaluated by a meal tolerance test (MTT) for incretin hormone measurements, and by the hyperglycemic clamp followed by an arginine test for assessing the beta-cell function and the acute insulin response. Others parameters as body composition and basic biochemistry will be also evaluated at Laboratory of Investigation on Metabolism and Diabetes - LIMED / State university of Campinas, Brazil. The characterization of the glucagon-like peptide-1 (GLP-1) production, dipeptidyl peptidase IV (DPP-IV) activity and/or endocrine pancreas incretin-response at aging, might be an interesting evidence to reinforce an incretin-based therapeutic approach for elderly onset type 2 diabetes.