At a glance

ClinicalIndex Comparison Record

N/ACompleted· 21 enrolled

Drug / intervention

FDG-PETother

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00846053

NCT00846053N/ACompleted

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FDG-PET Imaging in Young Cystic Fibrosis Patients

Washington University School of Medicine·interventional·Posted Feb 18, 2009·Updated Jul 24, 2018

In Brief

A clinical study evaluating FDG-PET for Cystic Fibrosis. Completed, enrolled 21 participants across 1 site.

Detailed Summary

The purpose of this research is to determine how a person's lungs will uptake \[18F\]fluorodeoxyglucose (FDG), as measured with positron emission tomography (PET) scanning in young cystic fibrosis (CF) patients.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsCystic Fibrosis

CountriesUnited States

CollaboratorsCystic Fibrosis Foundation

Timeline

N/ACompletedFinished

200920102011201220132014201520162017201820192020202120222023202420252026

Enrollment StartFeb 2009

First PostedFeb 2009

Primary CompletionFeb 2012

TodayJul 2026

First PostedFeb 18, 2009

Enrollment StartFeb 1, 2009

Primary CompletionFeb 1, 2012

TodayJul 2, 2026

Enrollment to primary: 3 yearsPosted 17.4 years ago

Interventions

FDG-PETother

All subjects underwent FDG-PET and low-dose volumetric CT imaging. After completing a transmission scan, \[18F\]FDG was injected intravenously at the start of dynamic scan acquisition. Regions of interest were drawn over multiple tomographic slices to determine average whole-lung and regional lung tissue \[18F\] FDG uptake. Patlak graphical analysis was used to determine the rate of \[18F\]FDG uptake from the blood input function and lung tissue activity curves, measured as the influx constant Ki (slope of the linear regression from the Patlak plot). Corrected Ki (i.e., Ki divided by the initial volume of distribution). Lung density was calculated from the attenuation image by standard methods.