CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 50 enrolled
Drug / intervention
Adenosine Stress Dual-source CTPother
Likely dose
Adenosine 140 mcg/kg/min continuous infusion for 2.5 minutes; IV iopamidol contrast 150 cc total; Siemens SOMATOM Definition CT scan with effective radiation dose approximately 13 mSvAI-extracted
Key inclusion· 3
  • ✓Prior adenosine or exercise stress SPECT exam with high likelihood of referral for invasive coronary angiography
  • ✓Age older than 40 years
  • ✓Able to comprehend and sign informed consent
Key exclusion· 9
  • ✕Acute coronary syndromes (unstable angina, NSTEMI, STEMI)
  • ✕Unstable clinical conditions including hemodynamic instability or arrhythmias
  • ✕Known allergy to iodinated contrast agents
  • ✕Atrial fibrillation

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00853671
NCT00853671N/ACompleted
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Myocardial Stress Perfusion Imaging With Dual Source CT

Massachusetts General Hospital·interventional·Posted Mar 2, 2009·Updated Dec 17, 2018

In Brief

A clinical study evaluating Adenosine Stress Dual-source CTP for Coronary Artery Disease. Completed, enrolled 50 participants across 1 site.

Detailed Summary

The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan. The investigators hypothesize that a coronary CTA protocol can be devised to obtain resting myocardial perfusion, myocardial perfusion after stress, and coronary anatomy. Hence, one diagnostic test will be able to detect the presence of coronary plaque as well as assess the functional significance of a stenosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Artery Disease
CountriesUnited States
CollaboratorsAstellas Pharma Inc

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 2, 2009
Enrollment StartApr 1, 2008
Primary CompletionApr 1, 2010
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 17.3 years ago

Interventions

Adenosine Stress Dual-source CTPother

Adenosine- continuous infusion at 140mcg/ kg/ min for 2.5 min; Iopamidol (IV contrast)- total dose of 150cc; Siemens SOMATOM Definition CT scanner (CT scan radiation) - effective radiation dose of approximately 13mSv (tube voltage 120kV, tube current 340mAs for one retrospectively gated cardiac CT with tube current modulation and two prospectively gated cardiac CTs on a Dual Source scanner) This is an observational trial, and all patients will undergo the Adenosine Stress Dual-source CTP procedure.