At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
An Exploratory, Multicenter, Investigator-blinded, Active-controlled Study to Investigate the Efficacy of Topical Azelaic Acid (AzA)15% Gel Twice Daily or Metronidazole Topical Gel 1% Once Daily, Plus Anti-inflammatory Dose Doxycycline (40mg) Once Daily in Subjects With Moderate Papulopustular Rosacea
In Brief
A Phase 4 clinical trial evaluating Azelaic acid (Finacea, BAY39-6251), Metronidazole (Metrogel), and 1 other intervention for Papulopustular Rosacea. Completed, enrolled 207 participants across 17 sites.
Detailed Summary
Subjects with moderate papulopustular rosacea will be treated either with azelaic acid 15% gel topically plus an anti-inflammatory dose of doxycyline (40mg) daily or with metronidazole 1% gel topically once daily plus an anti-inflammatory dose of doxycycline (40mg) over at total of twelve weeks to determine the rapidity of improvement, and the length of time to reach 25%, 50% and 75% clearing compared to baseline.
Study Details
Timeline
Interventions
Participants received topical azelaic acid gel 15% twice daily for 12 weeks
Participants received topical metronidazole 1% gel once daily for 12 weeks
Participants received systemic doxycycline 40 mg once daily for 12 week