CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 45 enrolled
Drug / intervention
Autologous Platelet Rich Plasma +2 morebiological
Likely dose
Autologous keratinocyte suspension in platelet-rich plasma sprayed onto wound bed with 10% Calcium Chloride solution in 10:1 proportionAI-extracted
Key inclusion· 2
  • ✓Skin graft donor site total body surface area <15%
  • ✓Skin graft donor site dimensions: 0.2mm deep, 30-40 cm² surface area
Key exclusion· 4
  • ✕Current use of immunosuppressive agents
  • ✕Current use of corticosteroids
  • ✕Terminal renal insufficiency
  • ✕Severe peripheral arterial disease

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00856934
NCT00856934Phase 1Completed
CompareCT.gov

A New Model to Enhance Wound Healing Using Autologous Keratinocytes in Platelet Concentrates - a Prospective Randomized Trial.

Centre Hospitalier Universitaire Vaudois·interventional·Posted Mar 6, 2009·Updated Mar 6, 2009

In Brief

A Phase 1 clinical trial evaluating Autologous Platelet Rich Plasma, Keratinocyte suspension, and 1 other intervention for Skin Graft. Completed, enrolled 45 participants across 1 site.

Detailed Summary

This prospective randomized trial evaluated the impact of autologous keratinocytes suspended in platelet concentrates on healing skin graft donor site wounds. It was hypothesized that the treatment would speed and improve wound healing.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSkin Graft
CountriesSwitzerland
Collaborators--

Timeline

Phase 1CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 6, 2009
Enrollment StartJun 1, 2005
Primary CompletionMar 1, 2006
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 17.3 years ago

Interventions

Autologous Platelet Rich Plasmabiological

Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.

Keratinocyte suspensionbiological

Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.

Standard dressingsother

Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.