At a glance
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Efficacy of Caffeine as an Adjuvant to Opioid Therapy in Cancer Pain: a Randomized, Double-blind, Placebo-controlled Trial
In Brief
A Phase 2 clinical trial evaluating Caffeine and Normal saline for Cancer and Pain. Completed, enrolled 41 participants across 2 sites.
Detailed Summary
Pain is a most common symptom and it has a high impact on quality of life in cancer patients. Many cancer patients have received opioid therapy, but also many of them have suffered from side effects of opioids. Drowsiness and confusion are common side effects of opioids. Caffeine is a well known psychostimulant,and it is widely used as an analgesics. Thus, the investigators aimed to prove the efficacy of intravenous caffeine administration as an adjuvant analgesics to opioids. At the same time, the investigators tried to find that the side effects of opioids could be ameliorated by caffeine.
Study Details
Timeline
Interventions
Intravenous injection of caffeine 200mg with 100ml of normal saline over 1 hour, once a day, for two days.
Intravenous injections of 100ml of normal saline over 1 hour, once a day, for two days