At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Nutritional and Contractile Regulation of Muscle Growth (Cycle 2)
In Brief
A Phase 1 clinical trial evaluating Rapamycin, Amino acid supplementation, and 3 other interventions for Sarcopenia. Completed, enrolled 144 participants across 1 site.
Detailed Summary
Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis. It is also prevalent among the elderly and in people who experience periods of physical inactivity and weightlessness. Muscle wasting can lead to overall weakness, immobility, physical dependence, and a greater risk of death when exposed to infection, surgery, or trauma. There is a need to develop scientifically based treatments that prevent muscle wasting. As one step towards such a goal, this study will examine the physiological and cellular mechanisms that regulate skeletal muscle growth.
Study Details
Timeline
Interventions
Single 16-mg oral dose
Nutritional drink containing essential amino acids
Leg extension exercises on a Cybex leg extension machine
Variable rate for 3 hours
Blood flow restriction for 5 minutes after the second biopsy
Leg extension exercises on a Cybex leg extension machine