CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 75 enrolled
Drug / intervention
Methadone +1 moredrug
Likely dose
Methadone 0.2 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00892606
NCT00892606Phase 4Completed
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Effectiveness of Pre-Operative Methadone Versus Morphine for Post-Operative Analgesia in Orthopedic Surgery Patients

University of Louisville·interventional·Posted May 4, 2009·Updated Jun 14, 2017

In Brief

A Phase 4 clinical trial evaluating Methadone and Morphine for Fracture and Pain, Postoperative. Completed, enrolled 75 participants across 1 site.

Detailed Summary

The investigators propose to compare analgesia by methadone and ketamine with a combination of morphine and ketamine in orthopedic surgery patients with moderate to severe pain. The investigators hypothesize that when given with ketamine before surgical incision, methadone is more effective than morphine in reducing postoperative morphine consumption and reducing pain during movement.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsFracture, Pain, Postoperative
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedMay 4, 2009
Enrollment StartJan 1, 2009
Primary CompletionDec 1, 2013
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 17.2 years ago

Interventions

Methadonedrug

Patients will receive 0.2 mg/kg of methadone IV immediately after intubation

Morphinedrug

Patients will receive 0.2 mg/kg of morphine IV immediately after intubation