At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Alternative Options to Minimize Niacin-Induced Flushing
In Brief
A clinical study evaluating Apple pectin, Aspirin 325 mg, and 1 other intervention for Hypercholesterolemia and Flushing. Completed, enrolled 100 participants across 1 site.
Detailed Summary
Niacin (Vitamin B3) is known to effectively and safely treat hypercholesterolemia. However, use of niacin is limited due to incidents of flushing which limits its acceptability. Some information suggests that applesauce can reduce the incidence and severity of flushing. The apple pectin in particular is thought to be the ingredient that affects this reaction. To determine if the apple pectin does affect flushing from niacin, the investigators will study the affects of isolated apple pectin in pill form. The investigators plan on recruiting 100 patients, and giving them 1000 mg of Niacin to induce flushing. Patients will be divided into 4 treatment groups and receive either pectin, aspirin, a combination of both, or placebo. Incidents and severity of flushing will be monitored for up to 6 hours post Niacin ingestion.
Study Details
Timeline
Interventions
Apple pectin 2000mg
Aspirin 325 mg
Placebo