At a glance
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A Phase 2 Study of Sequential and Concurrent Chemoradiation for Patients With Advanced Nasopharyngeal Carcinoma (NPC)
In Brief
A Phase 2 clinical trial evaluating docetaxel, cisplatin, and 4 other interventions for Stage II Lymphoepithelioma of the Nasopharynx and 5 related conditions. Completed, enrolled 26 participants across 1 site.
Detailed Summary
This phase 2 trial is studying whether giving a combination of docetaxel, cisplatin, and fluorouracil chemotherapy followed by the combination of cisplatin with radiation therapy works in treating patients with advanced nasopharyngeal cancer. Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Giving combination chemotherapy together with radiation therapy may kill more tumor cells.
Study Details
Timeline
Interventions
Given IV
Given IV
Given IV
Given IV
Undergo 3-dimensional conformal or intensity-modulated radiotherapy
Undergo 3-dimensional conformal or intensity-modulated radiotherapy