CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 63 enrolled
Drug / intervention
B12-Folic Acid, nitrous oxide +3 moredrug
Likely dose
B12-Folic Acid, nitrous oxide 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00901394
NCT00901394N/ACompleted
CompareCT.gov

Influence of Preoperative Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia

Washington University School of Medicine·interventional·Posted May 13, 2009·Updated Sep 16, 2020

In Brief

A clinical study evaluating B12-Folic Acid, nitrous oxide, Nitrous oxide (NO) and placebo, and 2 other interventions for Cardiovascular Abnormalities. Completed, enrolled 63 participants across 1 site.

Detailed Summary

The goal of this study is to find out if giving intravenous B-vitamins before general anesthesia with nitrous oxide prevents the increase in homocysteine, a metabolite that has been linked to cardiovascular complications.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiovascular Abnormalities
CountriesUnited States
CollaboratorsFoundation for Anesthesia Education and Research

Timeline

N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedMay 13, 2009
Enrollment StartMar 1, 2009
Primary CompletionJan 1, 2010
TodayJul 2, 2026
Enrollment to primary: 10 monthsPosted 17.1 years ago

Interventions

B12-Folic Acid, nitrous oxidedrug

IV vitamin B12 (cyanocobalamin) 1 mg, single administration over 30 min. IV folic acid, 5 mg, single administration over 30 min. Both diluted in 250 ml normal saline.

Nitrous oxide (NO) and placebodrug

60% nitrous oxide anesthesia plus saline

Placeboother

Saline

oxygen nitrogenother

60% air and oxygen mix.